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dc.contributor.authorZambrano-Huailla, Alexander
dc.contributor.authorZambrano-Huailla, Rommel
dc.contributor.authorGoicochea-Lugo, Sergio
dc.contributor.authorZavala-Flores, Ernesto
dc.contributor.authorGarcía-Berrocal, Jorge
dc.contributor.authorChau-Saravia, Angel
dc.contributor.authorPante-Medina, Carlos
dc.contributor.authorSalazar-Granara, Alberto
dc.identifier.citationZambrano A., Zambrano R., Goicochea S., Zavala E., García J., Chau A., Pante C., Salazar A. Study on inflammation and the nervous system of ethanol extract of jatropha curcas seed. Pharmacognosy Journal. 2016; 8(4): 335-340.es_PE
dc.description.abstractIntroduction: Jatropha curcas L. seeds are used in traditional medicine to treat a variety of diseases or conditions. The aim of this study is to evaluate effects on inflammation and the nervous system of ethanol extract of J. curcas seeds. Materials and methods: It was used 64 mice divided in 8 groups; respectively, 4 groups received 400, 600, 800 and 1000 mg/kg of ethanol extract of J. curcas seed; and the rest intake Diclofenac, Diazepam, Caffeine and a control group not received any substance. The effects on inflammation was evaluated by Carrageenan-Induced paw oedema test and by Paw skin temperature. Neurological symptoms of toxicity were evaluated using the Irwin test. For the analysis of quantitative variables were used the following tests: one-way ANOVA, Tukey, Shapiro-Wilk and Pearson correlation; for qualitative variables Chi square was used. Results: According to the paw oedema, it was showed a trend on an inflammatory effect of the seeds of J. curcas; this activity was statistically significant in doses of 1000 mg/kg. Also, the skin temperature measurements outcomes reveal a positive dose response manner. Regard to neurological manifestations, Straub tail was founded in doses of 400 mg/kg. Stereotypies were founded in doses of 400, 600, 800 and 1000 mg/kg throughout the evaluation. Conclusion: J. curcas seeds were showed an inflammatory effect. In addition, effects on the nervous system were founded as stereotypes and Straub tail.es_PE
dc.format.extentpp. 335-340es_PE
dc.publisherPharmacogn J.es_PE
dc.relation.ispartofseriesPharmacognosy Journal;vol. 8, no. 4
dc.sourceRepositorio Académico USMPes_PE
dc.sourceUniversidad San Martín de Porres - USMPes_PE
dc.subjectSistema nerviosoes_PE
dc.titleStudy on inflammation and the nervous system of ethanol extract of jatropha curcas seedes_PE
dc.typeinfo:eu-repo/semantics/articlees_PE Humana de San Martín de Porres. Facultad de Medicina Humana

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