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dc.contributor.authorHernández-Aguas, Jorday
dc.contributor.authorMontiel-Hernández, José Luis
dc.contributor.authorDe La Garza-Ramos, Myriam A.
dc.contributor.authorRuiz-Ramos, Rosa Velia
dc.contributor.authorEscamilla García, Erandi
dc.contributor.authorGuzmán-García, Mario Alberto
dc.contributor.authorAyón-Haro, Esperanza Raquel
dc.contributor.authorGarza-Elizondo, Mario Alberto
dc.date.accessioned2020-06-01T21:26:44Z
dc.date.available2020-06-01T21:26:44Z
dc.date.issued2017-06-06
dc.identifier.citationHernández J., Montiel JL., De La Garza MA., Ruiz RV., Escamilla E., Guzman MA., et al. Subchronic infection of porphyromonas gingivalis and tannerella forsythia stimulates an Immune response but not arthritis in experimental murine model. Int J Dent. 2017; 2017: 2052938.es_PE
dc.identifier.urihttps://hdl.handle.net/20.500.12727/6136
dc.description.abstractStudies have proposed that Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf) promote a nonspecific inflammatory response that could produce systemic disease. Oral inoculation of Pg and Tf on the immune and arthritis response was evaluated in BALB/C mice divided into four groups: (1) sham; (2) food contaminated with Pg/Tf; (3) complete Freund’s adjuvant (CFA) + Pg/Tf; and (4) CFA alone. CFA was administered subcutaneously on days 1 and 14. The arthritis response was monitored for 21 days after day 14 of CFA administration. IL-1β and IL-6 were determined in serum. T cell activation was evaluated by CD25 in salivary lymph nodes or mouse spleen. Pad inflammation appeared by day 19 in the CFA group, but animals with bacteria inoculation presented a delay. A significant increase in IL-6 was found in Groups 3 and 4, but not with respect to IL-1β. We observed an increase in CD25 in cells derived from cervical nodes and in animals with bacteria inoculation and CFA. A local immune response was observed in mice inoculated with Pg and Tf (T cell activation); a systemic response was observed with CFA. Since pad inflammation was delayed by bacterial inoculation this suggests that local T cell activation could decrease pad inflammation.es_PE
dc.description.sponsorshipProyectoProinnova-CONACYT Steripharma, Grant no. 141616.es_PE
dc.format.extent2052938es_PE
dc.language.isoenges_PE
dc.publisherHindawies_PE
dc.relation.ispartofurn:issn:2340-3152
dc.relation.ispartofseriesInternational Journal of Dentistry;vol. 2017
dc.relation.urihttps://doi.org/10.1155/2017/2052938es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_PE
dc.sourceRepositorio Académico USMPes_PE
dc.sourceUniversidad San Martín de Porres - USMPes_PE
dc.subjectInfeccioneses_PE
dc.subjectPorphyromonas gingivalises_PE
dc.subjectTannerella forsythiaes_PE
dc.subjectArtritis reumatoidees_PE
dc.titleSubchronic Infection of porphyromonas gingivalis and tannerella forsythia stimulates an immune response but not arthritis in experimental murine model
dc.typeinfo:eu-repo/semantics/articlees_PE
thesis.degree.nameMedicina Humanaes_PE
thesis.degree.grantorUniversidad de San Martín de Porres. Facultad de Medicina Humanaes_PE
thesis.degree.disciplineMedicinaes_PE
dc.publisher.countryGBes_PE
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.02.00es_PE


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