dc.contributor.author | Garred, Peter | |
dc.contributor.author | Larsen, F. | |
dc.contributor.author | Seyfarth, J. | |
dc.contributor.author | Fujita, Ricardo | |
dc.contributor.author | Madsen, Hans O. | |
dc.creator | Madsen, Hans O. | |
dc.creator | Fujita, Ricardo | |
dc.creator | Garred, Peter | |
dc.date.accessioned | 2016-03-15T15:13:47Z | |
dc.date.available | 2016-03-15T15:13:47Z | |
dc.date.issued | 2006-06-05 | |
dc.identifier.citation | Garred P., Larsen F., Seyfarth ., Fujit R., Madsen HO. Mannose-binding lectin and its genetic variants. Genes inmun 2006; 7: 85–94 | es_PE |
dc.identifier.uri | https://hdl.handle.net/20.500.12727/1542 | |
dc.description.abstract | Mannose-binding lectin (MBL) is a collagen-like serum protein that mediates activation of the complement system and is of
importance for host defence. Common variant alleles situated both in the promoter and structural region of the human MBL
gene (MBL2) influence the stability and the serum concentration of the protein. Epidemiological studies have suggested that
genetically determined variation in MBL serum concentration influences the susceptibility to and the course of different types of
infections, autoimmune, metabolic and cardiovascular diseases, but this is still a subject of debate. The fact that these genetic
variations are very frequent indicates a dual role for MBL in host defence. In this survey, we summarize the current molecular
understanding of human MBL genetics. | es_PE |
dc.description.sponsorship | Danish Medical Research Council,
The Danish Council for Development Research, The Novo Nordisk Research Foundation, The Danish Rheumatism Association, Health Insurance Denmark
Research Foundation, Copenhagen Hospital Corporation
Research Foundation, Rigshospitalet, EU y Concytec-Perú. | es_PE |
dc.format.extent | pp. 85-94 | es_PE |
dc.language.iso | eng | en_US |
dc.publisher | Genes and Immunity | es_PE |
dc.relation.ispartof | urn:issn:1476-5470 | |
dc.relation.ispartofseries | Genes and Immunity;n. 7 | |
dc.relation.uri | http://www.nature.com/gene/journal/v7/n2/full/6364283a.html | es_PE |
dc.rights | info:eu-repo/semantics/openAccess | es_PE |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es_PE |
dc.source | REPOSITORIO ACADÉMICO USMP | es_PE |
dc.source | Universidad de San Martín de Porres – USMP | es_PE |
dc.subject | Lectina de unión a manosa | es_PE |
dc.subject | Manosa | es_PE |
dc.subject | Lectina de unión a manosa de la vía del complemento | es_PE |
dc.subject | Inmunidad innata | es_PE |
dc.subject.ddc | 572.8 - Genética bioquímica | es_PE |
dc.title | Mannose-binding lectin and its genetic variants | |
dc.type | info:eu-repo/semantics/review | es_PE |
thesis.degree.name | Medicina Humana | es_PE |
thesis.degree.grantor | Universidad de San Martín de Porres. Facultad de Medicina Humana | es_PE |
thesis.degree.discipline | Medicina | es_PE |
dc.identifier.doi | http://dx.doi.org/10.1038/sj.gene.6364283 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.00 | es_PE |