Now showing items 1-10 of 20
Genetics and genomics in Peru: Clinical and research perspective
(Wiley Open Access, 2018-12-25)
Peruvians currently preserve in their DNA the history of 2.5 million years of human evolution and 150,000 years of migration from Africa to Peru or the Americas. The development of Genetics and Genomics in the clinical and ...
The current genomic landscape of western south america: andes, amazonia, and pacific coast.
(Society for Molecular Biology and Evolution, 2019-12)
Studies of Native South American genetic diversity have helped to shed light on the peopling and differentiation of the continent, but available data are sparse for the major ecogeographic domains. These include the Pacific ...
From colorectal cancer pattern to the characterization of individuals at risk: picture for genetic research in Latin America
(John Wiley & Sons Ltd, 2019-05-17)
Colorectal cancer (CRC) is one of the most common cancers in Latin America and the Caribbean, with the highest rates reported for Uruguay, Brazil and Argentina. We provide a global snapshot of the CRC patterns, how screening ...
Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors
(Springer Nature Limited, 2013-07-18)
In order to investigate the underlying genetic structure and genomic ancestry proportions of Peruvian subpopulations, we analyzed 551 human samples of 25 localities from the Andean, Amazonian, and Coastal regions of Peru ...
Genetic ancestry of families of putative inka descent
(Springer-Verlag GmbH Alemania, 2018-03-03)
This study focuses on the descendants of the royal Inka family. The Inkas ruled Tawantinsuyu, the largest pre-Columbian empire in South America, which extended from southern Colombia to central Chile. The origin of the ...
Precision medicine for locally advanced breast cancer: frontiers and challenges in Latin America
(ECancer Medical Science, 2019-01-22)
Advances in high-throughput technologies and their involvement in the ‘omics’ of cancer have made possible the identification of hundreds of biomarkers and the development of predictive and prognostic platforms that model ...
Mutational analysis of BRCA 1 and BRCA 2 genes in Peruvian families with hereditary breast and ovarian cancer
(Wiley Periodicals, Inc., 2017-06-28)
Background Breast cancer is one of the most prevalent malignancies in the world. In Peru, breast cancer is the second cause of death among women. Five to ten percent of patients present a high genetic predisposition due ...
Y chromosome sequences reveal a short beringian standstill, rapid expansion, and early population structure of native american founders
(Elsevier Ltd., 2018-12-20)
The Americas were the last inhabitable continents to be occupied by humans, with a growing multidisciplinary consensus for entry 15–25 thousand years ago (kya) from northeast Asia via the former Beringia land bridge [1, ...
Novel and known MYOC exon 3 mutations in an admixed Peruvian primary open-angle glaucoma population
(Molecular Vision, 2012)
Purpose: The aim of this study was to characterize a representative sample of the Peruvian population suffering openangle glaucoma (OAG) with respect to the myocilin gene (MYOC) mutations, glaucoma phenotype, and ancestry ...
Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion’s Disease in Amazonas, Peru
(Interdisciplinary Perspectives on Infectious Diseases, 2014)
Carrion’s disease (CD), is a human bartonellosis, that is, endemic in the Andes of Peru, Ecuador, and Colombia. Bartonella bacilliformis, a native hemotrophic bacteria, is the causative agent of CD, and the interaction ...