Now showing items 1-10 of 10
Maternal blood mitochondrial DNA copy number and placental abruption risk: results from a preliminary study
(e-Century Publishing, 2013-06-25)
Oxidative stress and impaired placental function – pathways implicated in the pathogenesis of placental abruption – have their origins extending to mitochondrial dysfunction. To the best of our knowledge, there are no ...
Genome-wide and candidate gene association studies of placental abruption
(e-Century Publishing, 2013-09-12)
Placental abruption (PA), a pregnancy-related vascular disorder, is a leading cause of maternal and perinatal morbidity and mortality. The success of identifying genetic susceptibility loci for PA, a multi-factorial heritable ...
A genome-wide association study of variations in maternal cardiometabolic genes and risk of placental abruption
(e-Century Publishing, 2012-11-05)
Accumulating evidence suggests that placental abruption has a complex multifactorial pathogenesis that involves cardiovascular risk and metabolic dysfunction. However, comprehensive assessment of variations in genes involved ...
Risk of placental abruption in relation to maternal depressive, anxiety and stress symptoms
Background Little is known about the influence of psychiatric factors on the etiology of placental abruption (PA), an obstetrical condition that complicates 1–2% of pregnancies. We examined the risk of PA in relation to ...
Circadian clock-related genetic risk scores and risk of placental abruption
(Elsevier Ltd., 2015-12)
Introduction The circadian clock plays an important role in several aspects of female reproductive biology. Evidence linking circadian clock-related genes to pregnancy outcomes has been inconsistent. We sought to examine ...
Maternal sleep duration and complaints of vital exhaustion during pregnancy is associated with placental abruption
(Informa Healthcare, 2015-02)
OBJECTIVE Sleep disorders are associated with cardiovascular complications and preterm delivery (PTD). Insufficient sleep results in metabolic alterations and increased inflammation, both known to contribute to placental ...
Placental mitochondrial DNA content and placental abruption: a pilot study
(BioMed Central, 2015-09-16)
Background Mitochondrial biogenesis and adequate energy production are important for embryogenesis and placentation. Previous studies documented alterations in maternal blood mitochondrial DNA (mtDNA) copy number—a marker ...
Childhood abuse, intimate partner violence, and placental abruption among Peruvian women
(Elsevier B.V., 2019-03)
Purpose Experiencing childhood abuse (CA) or intimate partner violence (IPV) has been linked to adverse pregnancy outcomes. We examined whether CA history and current IPV are independently and jointly associated with ...
Placental genome and maternal-placental genetic interactions: a genome-wide and candidate gene association study of placental abruption
While available evidence supports the role of genetics in the pathogenesis of placental abruption (PA), PA-related placental genome variations and maternal-placental genetic interactions have not been investigated. Maternal ...
Genetic variations and risk of placental abruption: a genome-wide association study and meta-analysis of genome-wide association studies
(Elsevier Ltd., 2018-04-16)
Introduction Accumulating epidemiological evidence points to strong genetic susceptibility to placental abruption (PA). However, characterization of genes associated with PA remains incomplete. We conducted a genome-wide ...