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dc.contributor.authorSandoval, Jose R.
dc.contributor.authorSalazar-Granara, Alberto
dc.contributor.authorAcosta, Oscar
dc.contributor.authorCastillo-Herrera, Wilder
dc.contributor.authorFujita, Ricardo
dc.contributor.authorPena, Sergio D. J.
dc.contributor.authorSantos, Fabricio R.
dc.date.accessioned2020-06-04T22:39:10Z
dc.date.available2020-06-04T22:39:10Z
dc.date.issued2013-07-18
dc.identifier.citationSandoval JR., Salazar A., Acosta O., Castillo W., Fujita R., Pena SDJ., et al. Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors. J Hum Genet. 2013; 58: 627–634.es_PE
dc.identifier.issn1435-232X (Digital)
dc.identifier.urihttps://hdl.handle.net/20.500.12727/6146
dc.description.abstractIn order to investigate the underlying genetic structure and genomic ancestry proportions of Peruvian subpopulations, we analyzed 551 human samples of 25 localities from the Andean, Amazonian, and Coastal regions of Peru with a set of 40 ancestry informative insertion–deletion polymorphisms. Using genotypes of reference populations from different continents for comparison, our analysis indicated that populations from all 25 Peruvian locations had predominantly Amerindian genetic ancestry. Among populations from the Titicaca Lake islands of Taquile, Amantani, Anapia, and Uros, and the Yanque locality from the southern Peruvian Andes, there was no significant proportion of non-autochthonous genomes, indicating that their genetic background is effectively derived from the first settlers of South America. However, the Andean populations from San Marcos, Cajamarca, Characato and Chogo, and coastal populations from Lambayeque and Lima displayed a low but significant European ancestry proportion. Furthermore, Amazonian localities of Pucallpa, Lamas, Chachapoyas, and Andean localities of Ayacucho and Huancayo displayed intermediate levels of non-autochthonous ancestry, mostly from Europe. These results are in close agreement with the documented history of post-Columbian immigrations in Peru and with several reports suggesting a larger effective size of indigenous inhabitants during the formation of the current country’s population.es_PE
dc.description.sponsorshipFAPEMIG y CNPq de Brasiles_PE
dc.format.extentpp. 627-634es_PE
dc.language.isoenges_PE
dc.publisherSpringer Nature Limitedes_PE
dc.relation.ispartofseriesJournal of Human Genetics;vol. 58
dc.relation.urihttps://doi.org/10.1038/jhg.2013.73es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceRepositorio Académico USMPes_PE
dc.sourceUniversidad San Martín de Porres - USMPes_PE
dc.subjectGrupo de ascendencia continental nativa americanaes_PE
dc.subjectAnálisis por conglomeradoses_PE
dc.subjectGrupo de ascendencia continental europeaes_PE
dc.subjectGenética de poblaciónes_PE
dc.subjectMutación INDELes_PE
dc.titleTracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestorses_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
thesis.degree.nameMedicina Humana
thesis.degree.grantorUniversidad de San Martín de Porres. Facultad de Medicina Humana
thesis.degree.disciplineMedicina


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