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Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity

dc.contributor.authorBarrera Tomas, Melissa
dc.contributor.authorTomas Chota, Gloria Eva
dc.contributor.authorSheen Cortavarría, Patricia
dc.contributor.authorFuentes Bonilla, Patricia
dc.contributor.authorInocente Camones, Miguel Angel
dc.contributor.authorContreras, Julio Santiago
dc.date.accessioned2020-06-01T21:26:14Z
dc.date.available2020-06-01T21:26:14Z
dc.date.issued2017
dc.identifier.citationBarrera M., Tomas GE., Sheen P., Fuente P., Inocente MA., Contreras JS. Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity. Revista Colombiana de Química. 2017; 46(3): 17-21.es_PE
dc.identifier.urihttps://hdl.handle.net/20.500.12727/6135
dc.description.abstractCompound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its anti-Mycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.es_PE
dc.format.extentpp. 17-21es_PE
dc.language.isoenges_PE
dc.publisherDepartamento de Química, Universidad Nacional de Colombiaes_PE
dc.relation.ispartofurn:issn:0036-3634
dc.relation.ispartofseriesRevista Colombiana de Química;vol. 46, no. 3
dc.relation.urihttp://dx.doi.org/10.15446/rev.colomb.quim.v46n3.61980es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_PE
dc.sourceRepositorio Académico USMPes_PE
dc.sourceUniversidad San Martín de Porres - USMPes_PE
dc.subjectIsoniazidaes_PE
dc.subjectMycobacterium tuberculosises_PE
dc.subjectHidrazonases_PE
dc.titleSynthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
dc.title.alternativeSíntesis de acil-hidrazona a partir del ácido úsnico e isoniazida y su actividad anti-Mycobacterium tuberculosises_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
thesis.degree.nameMedicina Humanaes_PE
thesis.degree.grantorUniversidad de San Martín de Porres. Facultad de Medicina Humanaes_PE
thesis.degree.disciplineMedicinaes_PE
dc.publisher.countryCOes_PE
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.02.00es_PE


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