Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity

Thumbnail
View/Open
Trabajo
(application/pdf: 1.297Mb)
Date
2017
Author(s)
Barrera Tomas, Melissa
Tomas Chota, Gloria Eva
Sheen Cortavarría, Patricia
Fuentes Bonilla, Patricia
Inocente Camones, Miguel Angel
Contreras, Julio Santiago
Metadata
Show full item record
Abstract
Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its anti-Mycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.
URI
https://hdl.handle.net/20.500.12727/6135
Collections
Subject
Publisher
Departamento de Química, Universidad Nacional de Colombia
Rights
info:eu-repo/semantics/openAccess
Related Resource(s)
http://dx.doi.org/10.15446/rev.colomb.quim.v46n3.61980
info:eu-repo/semantics/openAccess
Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess