dc.contributor.author | Gutierrez, Ericson Leonardo | |
dc.contributor.author | Ramos, Willy | |
dc.contributor.author | Seminario-Vidal, Lucia | |
dc.contributor.author | Tello, Mercedes | |
dc.contributor.author | Ronceros, Gerardo | |
dc.contributor.author | Ortega-Loayza, Alex G. | |
dc.date.accessioned | 2020-05-29T15:43:57Z | |
dc.date.available | 2020-05-29T15:43:57Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Gutierrez EL., Ramos W., Seminario L., Tello M., Ronceros G., Ortega AG. Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies. An. Bras. Dermatol. 2018; 93(2): 212-215. | es_PE |
dc.identifier.uri | https://hdl.handle.net/20.500.12727/6121 | |
dc.description.abstract | Background:
Previous studies have shown oxidative stress in pemphigus vulgaris and pemphigus foliaceus, nevertheless, it remains unknown whether a similar response is characteristic of endemic pemphigus foliaceus in Peru.
Objectives:
To determine the oxidative stress response in endemic pemphigus foliaceus patients and subjects with positive for anti-desmoglein1 antibodies (anti-dsg1) from endemic areas of Peru.
Subjects and Methods:
This is a cross-sectional study. The study population included 21 patients with Endemic Pemphigus foliaceus and 12 healthy subjects with anti-dsg1 antibodies from the Peruvian Amazon (Ucayali), as well as 30 healthy control subjects. Malondialdehyde, an indicator of lipid peroxidation by free radicals, was measured in serum.
Results:
We collected 21 cases of endemic pemphigus foliaceus, 15 of them with active chronic disease and 6 in clinical remission. Serum malondialdehyde values in patients with chronic active evolution and healthy subjects with anti-dsg1 antibodies were statistically higher than those of healthy controls (p<0.001). There was no significant difference between serum values of localized and generalized clinical forms.
Study limitations:
The main limitation of this present study is the small number of patients with endemic pemphigus and healthy subjects positive for desmoglein 1 antibodies.
Conclusions:
The increased serum levels of malondialdehyde in patients with chronic active endemic pemphigus foliaceus and healthy subjects from endemic areas with anti-dsg1 antibodies may suggest a contribution of systemic lipid peroxidation in the pathogenesis of endemic pemphigus foliaceus. | es_PE |
dc.format.extent | pp. 212-215 | es_PE |
dc.language.iso | eng | es_PE |
dc.publisher | Sociedade Brasileira de Dermatologia | es_PE |
dc.relation.ispartof | urn:issn:1806-4841 | |
dc.relation.ispartofseries | Anais Brasileiros de Dermatologia;vol. 93, no. 2 | |
dc.relation.uri | http://www.anaisdedermatologia.org.br/detalhe-artigo/102985/Estresse-oxidativo-em-pacientes-com-penfigo-foliaceo-endemico-e-individuos-saudaveis-com-anticorpos-antidesmogleina-1- | es_PE |
dc.relation.uri | https://doi.org/10.1590/abd1806-4841.20186211 | es_PE |
dc.rights | info:eu-repo/semantics/openAccess | es_PE |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | es_PE |
dc.source | Repositorio Académico USMP | es_PE |
dc.source | Universidad San Martín de Porres - USMP | es_PE |
dc.subject | Malondialdehído | es_PE |
dc.subject | Estrés Oxidativo | es_PE |
dc.subject | Pénfigo | es_PE |
dc.title | Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies | |
dc.type | info:eu-repo/semantics/article | es_PE |
thesis.degree.name | Medicina Humana | es_PE |
thesis.degree.grantor | Universidad de San Martín de Porres. Facultad de Medicina Humana | es_PE |
thesis.degree.discipline | Medicina | es_PE |
dc.publisher.country | BR | es_PE |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.00 | es_PE |